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While the all of our no. 1 objective, variations in the characteristics of the outcomes ranging from men and women sex had been analysed The latest designs having independence of amputation sensed dying just like the a competing exposure compared with the latest AFS patterns, including demise throughout the endpoint. For this specific purpose, we used Good and Gray’s method of imagine sub-distributional threat ratios (HRs) in the AFS design. The models included risk profiles of patients at baseline and additionally time-dependent occurrence of comorbidities or procedures in the follow-up period. Thus, we evaluated the interaction of sex with all variables in the Cox regression models. Two-sided P-values for the test of interaction of the two models were jointly adjusted using the Benjamini–Hochberg procedure 34 to control the false discovery rate (FDR) with respect to the multiple testing problem. False discovery rate-corrected P-values-denoted with P int-will be discussed and presented in the Supplementary material online. Additionally, we will quote the unadjusted two-sided interaction P-values for all models in the Supplementary material . All presented confidence intervals (CI) are standard unadjusted and all P-values relating to non-sex-interaction terms, i.e. the main effects in the full models or the effects in the subgroups, are two-sided, purely descriptive and unadjusted. We also calculated a sex-specific HR, which summarizes the sex-interaction terms, by a joint full model Cox regression with all comorbidities, but without additionally gender-interaction terms. I also performed various supplementary, explorative research. The brand new 30-big date mortality, amputation rate, and you can death or amputation had been analysed playing with multivariable logistic regression patterns. The two seasons knowledge costs off...
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